Graviola also known as soursop can reduce blood pressure and decreases heart rate.

Research has shown it to be effective against;

• Multi-drug antiviral resistant cancer cells and demonstrated it is;
• Anti-tumorous
• Anti-bacterial
• Antifungal
• Effective against Herpes simplex
• Cellular protector
• Antimalarial
• Antidepressant
• Sedative
• Broad spectrum internal and external antimicrobial
• Uterine stimulant
• Aids lactation
• Reduces blood pressure
• Lowers heart rate
• reduces fevers, spasms, coughs

Usage suggestions: We recommend you read the Technical Data Report to determine the best dosage for your condition.

Most commonly 1 dropperful taken 3 times a day is used. Diluting it with water, juice, or other beverages helps to reduce the  strength of the organic vodka.

After long-term use Parkinson-like symptoms can occur which disappear after you stop taking graviola, therefore, to avoid these symptoms it is often recommended that after taking it for 3 months you stop for 1 month before resuming medication .

Other actions

• Insecticidal
• Antiviral
• Parasitic infections

*with long term use take a probiotic due to the strong antimicrobial properties, do not use when pregnant or while taking Coenzyme Q10. This statement has not been evaluated by the FDA.  This product is not intended to diagnose, treat, or cure or prevent any disease

Clinical Summary

    Derived from a tree in the rain forests of Africa, South America, and Southeast Asia. The bark, leaves, root, and fruits have been used as traditional remedies in many countries.

Extracts of graviola have been shown to have; antiviral (1), antiparasitic, antirheumatic, astringent, emetic (2), antileishmanial and cytotoxic (3) (4) effects.

Graviola has also been shown to be effective against multidrug resistant cancer cells line (5) (4). There are no large scale studies in humans on the effects of graviola.

Alkaloids extracted from graviola may cause neuronal dysfunction and degeneration leading to symptoms reminiscent of Parkinson’s Disease (6).top which will disappear aftering stopping usage.

Purported uses; Cancer treatment, Herpes Infections, Parasitic infections, Sedation.

Top Constituents; Acetogenins, quinolines, isoquinolines, annopentocins and annomuricins (7). Coreximine and reticuline subfractions have been isolated from root bark (6).

Top Mechanism of Action;

Annonaceous acetogenins, a phytochemical isolated from the leaves, bark and twigs of graviola, are thought to be the active ingredient. The ethanolic extract of Annona muricata was found to inhibit the Herpes simplex virus (1). The ethyl acetate extract was found to be more active than the methanolic or hexanolic extracts. Extracts were shown to be effective against Leishmania braziliensis, L. panamensis promastigotes and the cancer cell line U 937 (3) and hepatoma cell lines(8) in vitro. Extracts were also shown to be lethal to the fresh-water mollusk Biomphalaria glabrata, which acts as a host for the parasitic worm Schistosoma mansoni (2).

Alkaloids from graviola have been shown to be detrimental to the survival of dopaminergic nerve cells in vitro. This may in turn lead to neuronal dysfunction and degeneration. Graviola-induced cell death was inhibited by the supplementation of glucose suggesting that cell death was caused by energy depletion (6).       

Graviola extracts have also been shown to be effective against the growth of Adriamycin resistant human mammary adenocarcinoma (MCF-7/Adr) by blocking the cancer cell’s access to ATP and by inhibiting the actions of plasma membrane glycoprotein (5).

Graviola may also have antidepressant activity due to its ability to stimulate serotonin receptors (7).

Top Pharmacokinetics; Little is known about the absorption, distribution, metabolism or excretion of graviola.

Top Adverse Reactions; Graviola may cause movement disorders and myeloneuropathy with symptoms similar to Parkinson’s disease (6).

Top Literature Summary and Critique; There are no large scale studies in animals or humans on the effects of graviola.

References:

1 Padma P, Pramod NP, Thyagarajan SP, Khosa RL. Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus. J Ethnopharmacol. 1998;61:81-3.

2 dos Santos AF,.Sant’Ana AE. Molluscicidal properties of some species of Annona. Phytomedicine. 2001;8:115-20.

3 Jaramillo MC, Arango GJ, Gonzalez MC, Robledo SM, Velez ID. Cytotoxicity and antileishmanial activity of Annona muricata pericarp. Fitoterapia 2000;71:183-6.

4 Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ et al. New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. J Nat.Prod. 2002;65:470-5.

5 Oberlies NH, Chang CJ, McLaughlin JL. Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. J Med Chem. 1997;40:2102-6.

6 Lannuzel A, Michel PP, Caparros-Lefebvre D, Abaul J, Hocquemiller R, Ruberg M.Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in Guadeloupe. Mov Disord. 2002;17:84-90.

7 Roman G. Tropical myeloneuropathies revisited. Curr.Opin.Neurol 1998;11:539-44.

8 Chen JC, Tsai CC, Chen LD, Chen HH, Wang WC. Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats. Am.J Chin Med. 2000;28:175-85.

9 Graviola.org. http://www.graviola.org/cgi/gpp.cgi?000001-000001-000000&../../1graviola/parsed_pages/graviola-data.htm. Accessed November 2003.top mall Heading

Dried & Fresh Flower Buds Extracted in 40% Organic Alcohol

Spilanthes expresses its powerful anti-bacterial, anti-fungal, immune and lymphatic stimulating properties

We make our tincture using 2 species of Spilanthes and Fresh flowerheads which are rich in spilanthol, the active ingredient proposed to be responsible for most of its biological activity.

Take a few drops, swish around in your mouth,  you will begin to salivicate….wildly and begin to experience a “buzzing” sensation as your nerve endings become excited, your circulation increases and the power of the herb diffuses through your mouth and gums. Your saliva contains antibacterial compounds that help protect your teeth and gums and combined with the strong bacteria fighting action of spilanthes this tincture is popular for helping to fight tooth decay.

The alkamide “spilanthol” is most commonly used to treat toothache, throat and gum infections and will also temporarily act as an anesthesia to deaden tooth pain while its bacteria fighting action fights tooth decay.

Traditionally spilanthes has many uses that have been screened and authenticated by researchers in vivo and in vitro.  Research has demonstrated its antibacterial properties and in vitro tests have demonstrated its strong effect against;

• E.coli
• Pseudomonas
• Salmonella
• Klebsiella pneumoniae
• Staphylococcus albus
• Growth of Candida albicans.

Based on these actions it may also be effective in treating cold and flu  infections,viral infections such as herpes cold sores, parasitic infections, and fungal or yeast infections causing ringworm, athlete’s foot, jock itch and vaginal infections.

An extra bonus is its potential for decreasing facial wrinkles by reducing muscle tension. It has also been reported  as an aphrodisiac and rumor has it there is a drink at Haru’s in New York called “Electriquila,” (or “Electric Eel”), a cocktail featuring the “buzz” of spilanthes in a traditional margarita reciepe and a few other additions.

 Use full strength for optimum effect

Suggested dosage; 15-30 drops 1-3x a day  (there are 20 drops/dropperful).

Properties of Curcumin extracted from Turmeric;

• A strong Anti-inflammatory
• Anti-arthritic
• Effective for inflammatory conditions (rheumatoid arthritis, ulcerative colitis and other inflammatory conditions.
• A blood and liver tonic
• Antioxidant
• Astringent
• Has been recommended as a treatment for chronic neurodegenerative diseases.
• Hemostatic
• Antispasmodic

Piperine extracted from black pepper helps turmeric become more bioavailable. Black pepper can relieve pain internally and topically,

We recommend diluting the tincture with water, juice, or other beverages to reduce the  strength of the organic vodka. 

Turmeric/black pepper combination extract;

• May target breast cancer stem cells without affecting normal tissue.
• Can help fight high cholesterol, obesity and diabetes. 
• Both turmeric and black pepper  are antioxidants and can help in memory loss and protect from cognitive impairment diseases.
• Tone the gut and protects against leaky gut, ulcers, promotes bile secretion
• Used with symptoms of cold and flu, bronchitis, sore throat, provides broad immune system support commonly used for chronic joint conditions, pain remedy, fungal infections like ringworm and athletes foot.